• Blood products and drugs affecting blood, Iron Complex
    Dosage form: Injection
    Strength: 50mg/ml (Dextran, Sorbitol)
    Indications/Special comments: Iron deficiency anaemia, where oral therapy is ineffective or impracticable
    Dosage Administration: Total dosage is calculated according to body-weight and the haemoglobin concentration of the blood, and tables are usually provided, consult product literature. The total dose requirement may be administered as a series of IM injections daily or once or twice weekly. Iron dextran is also given intravenously. Child under 14 years, not recommended
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  • Antivirals, Indinavir (IDV)
    Dosage form: Capsule
    Strength: 400mg
    Indications/Special comments: Treatment of HIV infection, in combination with two Nucleoside reverse transcriptase inhibitors and usually with low-dose ritonavir booster
    Dosage Administration: Oral: Adult: 800mg 8 hourly, 1 hour before or 2 hours after a meal; alternatively indinavir 800mg plus ritonavir 100 - 200mg 12 hourly (independent of meals). Child: 4 - 17 years: 500mg/m2 (maximum 800mg) 8 hourly
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  • Antineoplastics and Related Agents, Irinotecan Hydrochloride
    Dosage form: Injection
    Strength: 100mg/ml, 20mg/ml
    Indications/Special comments: Metastatic colorectal cancer in combination with fluorouracil and folinic acid or as monotherapy when treatment containing fluorouracil has failed. Treatment of epidermal growth factor receptor-expressing metastatic colorectal cancer after failure of chemotherapy that has included irinotecan (in combination with cetuximab). First-line treatment of metastatic carcinoma of the colon or rectum (in combination with fluorouracil, folinic acid and bevacizumab). First-line treatment of metastatic colorectal carcinoma (in combination with capecitabine with or without bevacizumab).
    Dosage Administration: See product leaflet
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  • Antineoplastics and Related Agents, Imatanib Mesylate
    Dosage form: Capsule
    Strength: 100mg, 400mg
    Indications/Special comments: Newly diagnosed Philadelphia positive (Ph+) chronic myeloid leukemia (CML). CML in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alpha treatment. Kit (CD117) positive metastatic/unresectable malignant gastrointestinal stomal tumors (GIST). Adjuvant treatment following resection of Kit (CD117) positive GIST. Paediatric patients with Ph+ CML after failure of bone marrow transplant or resistance to interferon-alpha. Adult patients with relapsed or refractory Ph+ acute lymphoblastic leukemia (ALL). Newly diagnosed Ph+ ALL (in combination with chemotherapy). Myelodysplastic/myeloproliferative disease (MDS/MPD) associated with platelet-derived growth factor receptor (PDGFR) gene re-arrangements. Aggressive systemic mastocytosis (ASM) without the D816V c-Kit mutation or with c-Kit mutational status unknown. Hypereosinophilic syndrome and/or chronic eosinophilic leukemia (HES/CEL). Unresectable, recurrent, or metastatic dermatofibrosarcoma protuberans (DFSP).
    Dosage Administration: Chronic Myeloid Leukemia: Oral: Adults: Chronic phase– 400mg once daily, may be increased to 600mg once daily; accelerated phase or blast crisis– 600mg once daily; may be increase to 800mg/day given as 400mg twice daily based on response and circumstances. Oral: Children: Newly diagnosed Ph+ CML: 340mg/m²/day (not to exceed 600mg); CML recurrent after failure of bone marrow transplant or resistance to interferon-alpha: 260mg/m² /day. Gastrointestinal Stromal Tumors: Oral: Adults: Metastatic or unresectable– 400mg/day; may be increase to 400mg twice daily if well tolerated and response insufficient; Adjuvant treatment after resection– 400mg/day. Ph+ Acute Lymphoblastic Leukemia: Oral: Adults: 600mg/day. Oral: Children: 340mg/m² /day (not to exceed 600mg). Myelodysplastic/Myeloproliferative Diseases: Oral: Adults: 400mg/day. Aggressive Systemic Mastocytosis: Oral: Adults: 400mg/day. For patients with eosinophilia– 100mg/day; increase to 400mg/day if well tolerated and response insufficient. Hypereosinophilic Syndrome and/or Chronic Eosinophilic Leukemia: Oral: Adults: 400mg/day. For patients with FIP1L1–PDGFRa fusion kinase 100mg/day; increase to 400mg/day if well tolerated and response insufficient. Dermatofibrosarcoma Protuberans: Oral: Adults: 800mg/day. Hepatic Impairment: Oral: Adults: decrease dose by 25% in severe hepatic impairment. Renal Impairment: Oral: Adults: CCr 40 – 59mL/min: Do not exceed dose of 600mg/day; CCr 20 – 39mL/min: decrease initial dose by 50%; increase as tolerated.
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  • Anti-inflammatory Agents, Influximab`
    Dosage form: Injection
    Strength: 100mg
    Indications/Special comments: Active rheumatoid arthritis (moderate to severe, with methotrexate). Active Crohn's disease (moderate to severe). Active psoriatic arthritis. Active ankylosing spondylitis. Active ulcerative colitis (moderate to severe) with inadequate response to conventional therapy: reducing signs and symptoms, and inducing and maintaining clinical remission and mucosal healing, and eliminating corticosteroid use. Plaque psoriasis (chronic severe).
    Dosage Administration: Rheumatoid Arthritis: IV: Adults: 3mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then repeat every 8 wk; dose may be adjusted in partial responders up to 10mg/kg or treatment as often as every 4 wk (to be used with methotrexate). Crohn's Disease: IV: Adults: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 8 wk; dose may be adjusted up to 10mg/kg in patients who initially respond and then lose their response. Children: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 8 wk. Ankylosing Spondylitis: IV: Adults: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 6 wk. Psoriatic Arthritis: IV: Adults: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 8 wk (to be used with or without methotrexate). Ulcerative Colitis: IV: Adults and Children =6 yr: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 8 wk. Plaque Psoriasis: IV: Adults: 5mg/kg initially, then repeat at 2 and 6 wk after initial infusion, then maintenance dose of 5mg/kg every 8 wk.
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  • Antifungals, Itraconazole
    Dosage form: Capsule
    Strength: 100mg
    Indications/Special comments: Vulvovaginal, oropharangeal or oesophageal candidiasis and dermatomycoses, not responding to conventional therapy. Useful for endemic mycoses, e.g., histoplasmosis, and may be an effective alternative to amphotericin B for aspergillosis.
    Dosage Administration: Oral: Adult: Vulvovaginal candidiasis: 200mg morning and evening for 1 day. Oropharyngeal candidiasis: 100mg (200mg in AIDS or neutropenia) daily for 15 days. Systemic mycoses: 200 - 400mg daily in single or 2 divided doses. Tinea Corporis, tinea cruris: 100mg daily for 15 days. Tinea pedis, tinea manuum: 100mg daily for 30 days
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  • Antidotes and other substances used in poisoning, Ipecac
    Dosage form: Syrup
    Strength: 7% Ipecac
    Indications/Special comments: An emetic for emergency use in the treatment of drug overdose and in some cases of poisoning.
    Dosage Administration: Oral: Adult: Emetic: 15 to 30ml followed immediately by one glass (240ml) of water. Dose may be repeated in twenty minutes if emesis does not occur. The dosage should be reversed by gastric lavage if emesis does not occur after the second dose. Child: Emetic: Children up to 1 year of age: 5 to 10ml. Children 1 - 12 years of age: 15ml, preceded or followed by ½ - 1 full glass (120 - 240ml) of water.
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  • Antibacterials, Isoniazid
    Dosage form: Tablet
    Strength: 100mg, 300mg
    Indications/Special comments: Tuberculosis treatment, in combination with other drugs (see notes and tables above); tuberculosis prophylaxis.
    Dosage Administration: Tuberculosis, treatment (combination therapy: Oral: Adult and Child: 5mg/kg (4 - 6mg/kg) daily (maximum, 300mg daily), or 10mg/kg 3 times weekly. Tuberculosis, treatment in critically ill patients unable to take oral therapy (combination therapy): IM: Adult: 200 - 300mg as single daily dose; Child: 10 - 20mg/kg daily. Tuberculosis, prophylaxis: Oral: Adult: 300mg daily for at least 6 months; Child: 5mg/kg daily for at least 6 months.
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  • Antibacterials, Imipenem + Cilastatin Sodium
    Dosage form: Injection
    Strength: 500mg
    Indications/Special comments: Treatment of lower respiratory tract infections, urinary tract infections, abdominal infections, gynaecologic infections, skin and skin structure infections, bone and joint infections, bacteremia, endocarditis, polymicrobic infections
    Dosage Administration: Mild infections: IV: Adults: 250 – 500mg every 6 hours. Moderate infections: 500mg every 6 – 8 hours or 1g every 8 hours. Serious infections: 500mg every 6 hr to 1g every 6 – 8 hr. Children =3 months [non-CNS infections]): 15 – 25mg/kg every 6 hours; higher doses have been used in older children with cystic fibrosis. Children 4 wk – 3 mo: 25mg/kg every 6 hr. Children 1 – 4 wk: 25mg/kg every 8 hr. Children <1 wk: 25mg/kg every 12 hr. IM: Adults: 500 – 750mg every 12 hr. Children: 10 – 15mg/kg every 6 hr. Renal dosing; See product insert
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  • Analgesic/Antipyretic/Anti-inflammatory, Ibuprofen
    Dosage form: Tablet
    Strength: 200mg, 400mg, 600mg, 800mg
    Indications/Special comments: Pain and inflammation in rheumatic disease, musculoskeletal disorders; mild to moderate pain including dysmenorrhoea, acute gout arthritis, postoperative analgesia; migraine; fever and pain in children.
    Dosage Administration: Adult: Antirheumatic: Oral: 1.2 to 3.2g a day in three or four divided doses. Reduce dose to lowest effective maintenance dose that gives symptom control. Note: Higher doses are generally required in rheumatoid arthritis than in osteoarthritis. Analgesia/pain/fever/ dysmenorrhoea: 200 - 400mg/dose every 4 - 6 hours (maximum daily dose: 1.2g, unless directed by physician).
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