• Antivirals, Stavudine
    Dosage form: Tablet
    Strength: 15mg
    Indications/Special comments: HIV infection in combination with other antiretroviral drugs when no suitable alternative available and when prescribed for shortest period possible.
    Dosage Administration: By mouth: Adult (body-weight up to 60 kg): 30mg every 12 hours, to be taken preferably at least 1 hour before food. Adult (body-weight 60 kg and above): 40mg every 12 hours, to be taken preferably at least 1 hour before food.
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  • Antiprotozoals, Sulphadiazine
    Dosage form: Tablet
    Strength: 500mg
    Indications/Special comments: Toxoplasmosis (with pyrimethamine); rheumatic fever
    Dosage Administration: Toxoplasmosis (in second and third trimesters of pregnancy): Adult: 3g daily in 4 divided doses. Toxoplasmosis in neonates: 85mg/kg daily in 2 divided doses; duration of treatment depends on whether the neonate has overt disease continue for 6 months, or is without overt disease but born to mother infected during pregnancy - treat for 4 weeks, followed by further courses, if infection confirmed. Toxoplasmosis in immunodeficiency: Adult: 4 - 6g daily in 4 divided doses for at least 6 weeks, followed by a suppressive dose of 2 - 4g daily.
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  • Antineoplastics and Related Agents, Sorafenib
    Dosage form: Tablet
    Strength: 200mg
    Indications/Special comments: Treatment of advanced renal cell carcinoma when treatment with interferon alfa or interleukin-2 has failed or is unsuitable. Treatment of progressive, locally advanced, or metastatic, differentiated thyroid carcinoma that is refractory to radioactive iodine. Treatment of hepatocellular carcinoma.
    Dosage Administration: Treatment of advanced renal cell carcinoma when treatment with interferon alfa or interleukin-2 has failed or is unsuitable. Treatment of progressive, locally advanced, or metastatic, differentiated thyroid carcinoma that is refractory to radioactive iodine. Treatment of hepatocellular carcinoma.By mouth: Adult: 400mg twice daily, for dose adjustments due to side effects, consult product literature
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  • Anti-inflammatory Agents, Sulphasalazine
    Dosage form: Tablet (ER)
    Strength: 500mg
    Indications/Special comments: Severe rheumatoid arthritis
    Dosage Administration: Adult: initially 500mg daily, increased by 500mg at intervals of 1 week to a maximum of 2 - 3g daily in divided doses.
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  • Antidotes and other substances used in poisoning, Sodium Polystyrene Sulphonate
    Dosage form: Suspension
    Strength: 15g/60ml
    Indications/Special comments: Treatment of hyperkalaemia
    Dosage Administration: Adult: Oral: 15g (60ml) 1 - 4 times/day. Child: Oral: 1g/kg/dose every 6 hours.
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  • Antidepressants, Sertraline Hydrochloride
    Dosage form: Tablet
    Strength: 25mg, 50mg, 100mg
    Indications/Special comments: Obsessive-Compulsive Disorder (OCD)–Panic Disorder, Posttraumatic Stress Disorder (PTSD)–Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder, Major Depressive Disorder
    Dosage Administration: Depression: Oral: Adult: initially 50mg daily, usual range 50 - 100 mg/day. May be increased, if necessary, by increments of 50mg over several weeks up to a maximum of 200mg/day. OCD: the minimum effective dose is 50mg/day. Increase, if necessary, in 50mg increments over several weeks up to a maximum of 200mg/day. Panic disorder: initially 25mg daily, increased to 50mg/day after 1 week, and thereafter, if necessary, in 50mg increments up to a maximum of 200mg/day. Child: OCD: 6 - 12 years: initial: 25mg once daily; 13 -17 years: initial: 50mg once daily.
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  • Anticonvulsants, Sodium Valproate
    Dosage form: Tablet
    Strength: 125mg, 250mg, 500mg
    Indications/Special comments: For all forms of epilepsy
    Dosage Administration: Oral: Adult: initially, 600mg daily given in 2 divided doses, preferably after food, increasing by 200mg/day at 3 days intervals to a max. of 2.5g daily in divided doses, usual maintenance 1 - 2g daily (20 - 30 mg/kg daily); Child up to 20kg, initially 20mg/kg daily in divided doses, may be increased provided plasma concentrations monitored (above 40mg/kg daily also monitor clinical chemistry and haematological parameters); over 20kg, initially 400mg daily in divided doses increased until control (usually in range of 20 - 30mg/kg daily); max. 35mg/kg daily.
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  • Anticonvulsants, Sodium Valproate
    Dosage form: Syrup
    Strength: 250mg/5ml
    Indications/Special comments: For all forms of epilepsy
    Dosage Administration: Oral: Adult: initially, 600mg daily given in 2 divided doses, preferably after food, increasing by 200mg/day at 3 days intervals to a max. of 2.5g daily in divided doses, usual maintenance 1 - 2g daily (20 - 30 mg/kg daily); Child up to 20kg, initially 20mg/kg daily in divided doses, may be increased provided plasma concentrations monitored (above 40mg/kg daily also monitor clinical chemistry and haematological parameters); over 20kg, initially 400mg daily in divided doses increased until control (usually in range of 20 - 30mg/kg daily); max. 35mg/kg daily.
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  • Antibacterials, Streptomycin Sulphate
    Dosage form: Powder for Injection
    Strength: 1g base in vial
    Indications/Special comments: Tuberculosis, in combination with other drugs
    Dosage Administration: Tuberculosis, 6-month regimen (combination therapy): Oral: Adult: 10mg/kg (rifampicin) and 5mg/kg (isoniazid) daily. Alternatively, 10mg/kg (rifampicin) and 10mg/kg (isoniazid) 3 times a week.
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  • Antibacterials, Spectinomycin
    Dosage form: Injection
    Strength: 2g in vial
    Indications/Special comments: Uncomplicated and disseminated gonorrhoea; adult and neonatal gonococcal conjunctivitis; chancroid.
    Dosage Administration: Uncomplicated gonococcal infections and chancroid: deep IM injection: Adult: 2g as a single dose (may be increased to 4g as a single dose divided between 2 injection sites in difficult to treat cases and where there is known antibiotic resistance). Disseminated gonococcal infections: Deep IM injection: Adult: 2g twice daily for 7 days. Neonatal gonococcal conjunctivitis: Deep IM injection: Neonate: 25mg/kg (maximum 75mg) as a single dose.
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